SOCRI in & out DETOX



SOCRI in & out DETOX is a balanced anti-pollution plant complex in a carrier of polyglyceryl-4. It is a detoxifying agent and protects tissue structure.
Our bodies are exposed to toxins every day through external contact with the environment, whether we are at home or at work. They are in the air we breathe, in smog and particulates, in cleansers and beauty products, in UV radiation and tobacco smoke. When our bodies absorb these substances, they have a negative effect on the metabolism, which can in turn lead to more serious and debilitating problems.
SOCRI in & out DETOX is a powerful antioxidant that activates the enzymatic processes of detoxification.

  • It protects and defends the skin from pollutants.
  • It prevents the signs of skin ageing from forming.
  • It protects against environmental stress factors.
  • It activates the enzymes that control the process of detoxification.

The first step in the detoxification process requires activity by enzymes, which can deactivate some chemical substances directly by neutralizing them. However, there are some toxins which cannot be deactivated and must instead be converted into an intermediate form. This modified intermediate form is actually considered to be more toxic than the original and requires Phase II enzyme activity to complete the detoxification cycle.
2 enzymatic mechanisms are involved. The first activates the metabolism while modifying the chemical bonds, and the second uses antioxidant enzymes to complete the detoxification process. The combined activity helps protect the skin cells against toxins and reagents, dangerous molecules for the health of cells and the body.

Nobiletin is a flavonoid derived from citrus. Specifically, it is extracted from the peel of Citrus Aurantium. In addition to being a powerful antioxidant, it also interferes with biological inflammatory processes, inhibiting the expression of the genes involved in the inflammatory process by blocking NF-kB from binding to DNA. Treatment of skin cells with nobiletin has also reduced inflammation caused by UVB radiation. It is able to block and inhibit the activity of free radicals, which can potentially be responsible for interfering in various metabolic processes. Such interference, if allowed to persist and increase, can cause permanent damage to the health of the skin and of our body.

Brassica Oleracea Extract (Broccoli) is rich in a compound belonging to the isothiocyanate group: sulphoraphane. The Sulphoraphane found in broccoli is a Phase II enzymatic detoxification activator, improves the skin cells’ resistance to environmental pollution, helps to eliminate catabolites, and has anti-ageing properties.

Solanum Aethiopicum (or Ethiopian eggplant) contains a unique and varied range of active substances. In particular, the polyphenols within it have anti-ageing and anti-allergenic properties, are powerful skin moisturisers and nutrients, strengthen the immune system and combat free radicals.

SOCRI in & out DETOX protects the skin from pollution and from environmental stress factors, combats the visible signs of skin ageing, helps to prevent damage to DNA and activates the enzymatic detoxification process.

  • Detoxifying activity: studies conducted on the enzymes involved in Phase II detoxification showed that these increased significantly in a dose-dependent fashion. These enzymes protect against oxidative stress, inhibiting the formation of mediators that induce cell apoptosis, and combat the formation of free radicals.
  • Soothing activity: in vivo studies were conducted using patch tests to evaluate this type of activity. The parameters evaluated were TEWL (transepidermal water loss) and erythema. The results showed that SOCRI in & out DETOX in a 2% concentration significantly reduced both of these factors, indicating a soothing effect.
  • Cleansing activity: our skin is one of the organs best able to eliminate impurities and catabolites. Through cleansing we can partially detoxify the skin, a process activated by SOCRI in & out DETOX. In vivo studies have shown that a cleanser containing 2% SOCRI in & out DETOX can, after only 20 minutes, improve the skin’s hydration (+ 5%) and pore cleanliness (+ 27%), as well as reduce blackheads (-13%) and the peeling caused by dehydration (-37%).

SOCRI in & out DETOX is ideal for use in all types of cleansers, protective day creams, regenerating night creams and detoxifying creams.
The recommended percentage of use ranges from 1% to 5% depending on the type of formulation to be developed. As a rule, a 2% concentration is used. Products containing SOCRI in & out DETOX are generally used 1 or 2 times per day. We recommend adding SOCRI in & out DETOX at a temperature of less than 50°C, during the cooling phase, or else directly in the aqueous phase. 
With regard to the clinical safety evaluation of SOCRI in & out DETOX, patch testing found the product to be safe and non-irritating at a 2% concentration.